Target name | Gene symbol | Target family | Compounds screened | Positives | Hit percent |
---|---|---|---|---|---|
Adenosine A3 | ADORA3 | GPCR | 2834 | 832 | 29.35 |
Dopamine D2 short | DRD2 | GPCR | 2606 | 346 | 13.27 |
Mu-type opioid | OPRM1 | GPCR | 2573 | 364 | 14.14 |
Muscarinic M1 | CHRM1 | GPCR | 2533 | 916 | 36.16 |
Seritonin 5-HT2A | HTR2A | GPCR | 2391 | 526 | 21.99 |
Adenosine A1 | ADORA1 | GPCRS | 2378 | 102 | 4.28 |
NE transporter | SLC6A2 | Transporters | 2360 | 393 | 16.65 |
Seritonin 5-HT2B | 5-HT2B | GPCR | 2316 | 823 | 35.53 |
Dopamine D1 | DRD1 | GPCR | 2301 | 241 | 10.47 |
Seritonin -5HT1A | HTR1A | GPCR | 2290 | 290 | 12.66 |
Histamine H1 | HRH1 | GPCR | 2286 | 214 | 9.36 |
Muscarinic M2 | CHRM2 | GPCR | 2253 | 513 | 22.76 |
Adrenergic β1 | ADRB1 | GPCR | 2252 | 60 | 2.66 |
Acetylcholineesterase | ACHE | Other-enzymes | 2245 | 418 | 18.61 |
5HT transporter | SLC6A4 | Transporters | 2241 | 799 | 35.65 |
GABA A (Cl − channel receptor) | GABRA1(CL-) | Ion-channel | 2238 | 448 | 20.01 |
Adrenergic α1A | ADRA1A | GPCR | 2210 | 380 | 17.19 |
Monoamine oxidase | MAOA | Other-enzymes | 2204 | 20 | 0.90 |
Seritonin 5-HT3 | 5-HT3 | Ion-channel | 2130 | 50 | 2.34 |
HIV-1 Protease | HIV1-PR* | Other-enzymes | 2110 | 46 | 2.18 |
Adrenergic α2A | ADRA2A | GPCR | 2020 | 196 | 9.70 |
Adrenergic β2 | ADRB2 | GPCR | 1973 | 76 | 3.85 |
PPARgamma | PPARG | Nuclear receptor | 1955 | 194 | 9.92 |
Ca2 + channel (Diltiazem site) | CACNA1C | Ion-channel | 1942 | 473 | 24.35 |
Nicotinic muscle-type | CHRNA1 | Ion-channel | 1899 | 173 | 9.11 |
Prostaglandin F | PTGFR | GPCR | 1897 | 73 | 3.84 |
Histamine H3 | HRH3 | GPCR | 1864 | 215 | 11.53 |
Xanthine oxidase | XDH* | Other-enzymes | 1831 | 49 | 2.67 |
Glucocorticoid | NR3C1 | Nuclear-receptor | 1816 | 76 | 4.18 |
Cyclooxygenase 2 | PTGS2 | Other-enzymes | 1799 | 192 | 10.67 |
Choleystokinin 1 | CCKAR | GPCR | 1792 | 139 | 7.75 |
Matrix metallopeptidase 9 | MMP9 | Other-enzymes | 1787 | 38 | 2.12 |
Angiotensin receptor II | AGTR1 | GPCR | 1762 | 45 | 2.55 |
GABA-A (Benzodiazepene site) | GABRA1(Benzo) | Ion-channel | 1645 | 329 | 20 |
Histamine H2 | HRH2 | GPCR | 1644 | 123 | 7.48 |
Cannabinoid CB1 | CNR1 | GPCR | 1609 | 67 | 4.16 |
Phosphodiesterase 3B | PDE3B | Other-enzymes | 1563 | 66 | 4.22 |
ZAP70 Kinase | ZAP70 | Kinases | 1484 | 25 | 1.68 |
CDK2 Kinase | CDK2 | Kinases | 1465 | 61 | 4.16 |
GSK3 beta | GSK3B | Kinases | 1394 | 65 | 4.66 |
Estrogen alpha | ESR1 | Nuclear-receptor | 1389 | 7 | 0.50 |
ABL1 Kinase | ABL1 | Kinases | 1328 | 236 | 17.77 |
GSK3 alpha | GSK3A | Kinases | 1285 | 97 | 7.54 |
Androgen | AR | Nuclear-receptor | 1234 | 86 | 6.96 |
Glutamate (PCP) | PCP* | Ion-channel | 1187 | 6 | 0.50 |
Glycine receptor (Strychnine insensitive) | Glycine* | Ion-channel | 1145 | 2 | 0.17 |
Nicotinic neuronal-type (alpha-BGTX insens.) | CHRNA4 | Ion-channel | 951 | 9 | 0.94 |
Angiotensin converting enzyme | ACE2 | Other-enzymes | 832 | 58 | 6.97 |
Kappa-type opioid | OPRK1 | GPCR | 428 | 89 | 20.79 |
Phosphodiesterase 4D2 | PDE4D2 | Other-enzymes | 133 | 15 | 11.27 |