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Table 2 Examples of mode of action annotations based on ChEMBL data

From: KNIME workflow for retrieving causal drug and protein interactions, building networks, and performing topological enrichment analysis demonstrated by a DILI case study

$action_type$ = "ACTIVATOR" =  > 1
$action_type$ = "AGONIST" =  > 1
$action_type$ = "ANTAGONIST" =  > 2
$action_type$ = "BINDING AGENT" =  > 3
$action_type$ = "BLOCKER" =  > 2
$action_type$ = "MODULATOR" =  > 3
$action_type$ = "NEGATIVE ALLOSTERIC MODULATOR" =  > 2
$action_type$ = "NEGATIVE MODULATOR" =  > 2
$action_type$ = "POSITIVE MODULATOR" =  > 1
$action_type$ = "RELEASING AGENT" =  > 3
$action_type$ = "STABILISER" =  > 3