Table 1 The distribution of biological activity (IC50/EC50) of data records
From: VGSC-DB: an online database of voltage-gated sodium channels
Targets | Number of records in IC50/EC50 (nM) range | ||||
|---|---|---|---|---|---|
0–10 | 10–100 | 100–1000 | 1000–10,000 | > 10,000 | |
Nav1.1 | 4 | 8 | 13 | 30 | 25 |
Nav1.2 | 22 | 31 | 61 | 120 | 70 |
Nav1.3 | 2 | 7 | 9 | 16 | 83 |
Nav1.4 | 4 | 27 | 79 | 209 | 96 |
Nav1.5 | 2 | 36 | 154 | 556 | 806 |
Nav1.6 | 6 | 6 | 18 | 12 | 15 |
Nav1.7 | 371 | 782 | 1122 | 725 | 280 |
Nav1.8 | 24 | 55 | 81 | 29 | 34 |
Nav1.9 | – | – | 1 | 3 | 21 |
Total | 435 | 952 | 1538 | 1700 | 1430 |