Figure 1

TMACC interpretation of ACE inhibitors. TMACC activity colour scheme: red for very negative activity; orange for negative activity; green for neutral activity; yellow for positive activity and blue for very positive activity. A) molecule 87, captopril; the sulfhydryl zinc binding group, P1' methyl group, central carbonyl and the C-terminal carboxylate are all shown in blue, indicating that they provide a positive contribution to the activity of the molecule. B) molecule 64, enalaprilat; the carboxylate zinc binding group, P1' methyl group, central carbonyl and the C-terminal carboxylate are all shown to provide a positive contribution to the activity of the molecule. C) molecule 65, lisinopril; the carboxylate zinc binding group, P1' lysyl group, central carbonyl and the C-terminal carboxylate all provide a positive contribution to the activity of the molecule.