Table 2 More Query compounds and related biological activities retrieved from WENDI
Query CID | 44246407 | 44246344 |
|---|---|---|
Reported activities | Inhibitor/activator of human alpha glucosidase | None |
Tumor Cell Line Predictive models | 50-60% probability of activity in melanoma, leukemia, otherwise <50% probability | Strong prediction (>70% probability) of activity in prostate, colon, non-small cell lung, breast, malanoma, leukemia, ovarian cancers. 50-60% probability in all other cell lines. |
Bioassay activities & gene relationships of similar compounds | similar compound shows active as an inhibitor of MEK-5 Kinase 2 mutant | Similar compounds show active in NCI ovarian cancer cell line (IGROV1), breast cancer cell line (MB-435); non small cell lung cancer (H23); MLPCN Alpha-synuclein 5'UTR binding activation (Parkinson's disease); Leishmania promastigote inhibition; NCI yeast anticancer screen; RAM inhibition (STAT3); |
Bioassay inactives of similar compounds | similar compounds show inactive in SIP3 antagonists assay, hERG blockers of proarrythmic agents. and 14-3-3- protein interaction modulation | similar compounds inactive in RNase H inhibition, NCI non small cell lung cancer (H23) and Leukemia (L1210); NCI yeast anticancer screen; 14-3-3 protein interaction modulators; SIP3 antagonists |
CTD gene relationships of similar compounds | A similar compound associated with adenomatous polyposis | Similar compounds associated with Alzheimer's disease |
Activities of similar marketed drugs | None | None |
Insights from similar compounds in journal articles (MEDLINE) | None | None |
Interpretation | None | None |