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Table 3 Ranking of top-50 targets by numbers of compounds and documents.

From: Analysis of in vitrobioactivity data extracted from drug discovery literature and patents: Ranking 1654 human protein targets by assayed compounds and molecular scaffolds

Rank Approved
Symbol
Entrez Gene
ID
No of
compounds
No of
documents
1 F10 2159 42869 690
2 CNR1 1268 29658 578
3 KDR 3791 27661 350
4 MAPK14 1432 24568 309
5 DRD3 1814 23405 508
6 F2 2147 22853 768
7 HRH3 11255 22748 407
8 TACR1 6869 21908 626
9 MMP13 4322 20590 315
10 CNR2 1269 19712 464
11 MMP1 4312 17525 394
12 ADORA2A 135 17181 532
13 EGFR 1956 16581 445
14 SLC6A4 6532 16571 403
15 MMP9 4318 16537 344
16 HTR6 3362 16457 504
17 MMP2 4313 16405 310
18 HTR2C 3358 15945 475
19 CRHR1 1394 15550 222
20 MC4R 4160 15084 299
21 HTR2A 3356 14622 509
22 NPY5R 4889 14547 216
23 CCR3 1232 14136 114
24 OPRM1 4988 13394 466
25 DPP4 1803 13057 308
26 REN 5972 12894 438
27 CALCRL 10203 12615 137
28 CTSS 1520 12426 177
29 CHRM3 1131 12398 412
30 CCR2 729230 12208 160
31 DRD2 1813 12050 564
32 MET 4233 11745 118
33 ADORA1 134 11644 480
34 GSK3B 2932 11283 198
35 CCR5 1234 11179 197
36 CXCR2 3579 10851 183
37 SRC 6714 10838 282
38 MCHR1 2847 10821 209
39 EDNRA 1909 10769 260
40 NR3C1 2908 10687 199
41 EDNRB 1910 10601 239
42 HTR1A 3350 10015 627
43 OPRK1 4986 9690 375
44 TACR2 6865 9676 301
45 SLC6A2 6530 9671 272
46 ADORA3 140 9533 457
47 OPRD1 4985 9500 394
48 HSD11B1 3290 9334 151
49 ELANE 1991 9173 308
50 TRPV1 7442 8988 150