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Figure 5 | Journal of Cheminformatics

Figure 5

From: Visualizing chemical structure-subcellular localization relationships using fluorescent small molecules as probes of cellular transport

Figure 5

The observed staining patterns in relation to the predicted, cellular staining patterns of styryl probes. A) Plot shows the calculated, predicted percent accumulation of probes in mitochondria or lysosomes, relative to the observed staining patterns (YES means the compounds were visually scored as staining mitochondria or lysosomes; NO means the compounds were visually scored as staining cytoplasmic (or plasma) membranes, nuclei or nucleoli). B) The Accuracy of the predicted, subcellular distributions of probes to mitochondria or lysosomes relative to the observed mitochondrial or lysosomal (or nonmitochondrial and nonlysosomal) staining patterns, as shown in A), plotted as a function of the threshold % predicted mass accumulation in mitochondria or lysosomes. Each threshold % mass accumulation is used to distinguish between those probes that are predicted to localize to mitochondria or lysosomes vs. those that are not. C) Plot shows the calculated, predicted percent accumulation in cytoplasmic membranes, relative to the observed staining patterns (YES means the compounds were visually scored as staining cytoplasmic or plasma membrane; NO means the compounds were visually scored as staining mitochondria, lysosomes nuclei or nucleoli). D) The Accuracy of the predicted, subcellular localization categories of the probes in cytoplasmic (or plasma) membranes relative to the observed cytoplasmic (or plasma) membrane staining pattern vs. other observed staining patterns as shown in B), plotted as a function the threshold % predicted mass accumulation in mitochondria or lysosomes.

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