Figure 12

Two different types of outlier trends, which are likely to explain the formation of 2 clusters of outliers. VEGFR3, ACK1 and LYN show consistently high SAR similarity with other kinases at both low and high distances, with lower SAR similarity against some kinases at high distances (see graphs below). CSK21, CSK22, IGF1R and WNK2 show significantly higher SAR similarity with other kinases at low distances than at higher distances, but with very high variance of the data points: in many cases, neighboring kinases show low SAR similarity or distant kinases show high SAR similarity (see graphs above). Regardless, 2 different types of outlier trends were observed, possibly explaining the grouping of the outliers in 2 different clusters in the MDS plot.