Figure 3

Compound promiscuity. The number of shared active compounds with other (1 or more) kinases is shown in dark gray, whereas the average number of kinases these active compounds are shared with for each kinase is shown in light gray. Only 1 kinase (NEK7) does not share any active compounds with other kinases. Of all kinases, 80% share over 20 active compounds which is of importance for establishing meaningful kinase SAR relationships. These compounds are shared with 51 kinases on average, suggesting the compouunds in the dataset to be relatively promiscuous on average.