Kinome tree constructed with a distance matrix based on fingerprint enrichments. Kinases were colored based on the classification of kinase groups as defined by Manning et al. Overall, kinases from the same group (with the same color) tend to group in the same cluster. CDK and CLK kinases from the CMGC group and AGC kinases are clearly grouped together. However, kinases from the same family or group do not always cluster together, as for example is the case with MK12 (p38γ) and MK13 (p38δ), which are both isolated from each other. On the other hand, the very similar proteins MK14 (p38α) and MK11 (p38β) are located close to each other.