Figure 7

Compound promiscuity for kinase outlier group 1 and kinase outlier group 2. Kinase outlier group 1 is based on distances generated from fingerprint enrichment profiles, whereas kinase outlier group 2 is based on distances generated from Tanimoto comparison between bioactivity fingerprints of kinases, as performed earlier by Bamborough et al.[21]. Given that the kinases in outlier group 1 share over 7 times as many active compounds with other kinases in the dataset as compared to kinases from outlier group 2, kinase outliers from group 1 have more robust data for SAR similarity comparison and are therefore more likely to be genuine outliers (since their character as outliers is based on more comprehensive underlying data).