- Poster presentation
- Open Access
Simulation of the influence of oxygen on the chemical stage of radiobiological mechanism using Petri nets
Journal of Cheminformatics volume 6, Article number: P12 (2014)
The radiobiological effect of densely ionizing ends of primary or secondary charged particles may be influenced significantly by processes running in the chemical stage of radiobiological mechanism; especially the influence of present oxygen may be very important. The effect of its or of other species (radiomodifiers) present in water medium during irradiation may be studied with the help of corresponding mathematical models. The model based on the use of Petri nets will be proposed and described.
Two parallel processes, i.e., diffusion of radicals and their chemical reactions, running in corresponding radical clusters formed during energy transfer may be represented with the help of the given model. A great number of chemical species may be easily taken into account. The model enables to study the concentrations of individual radicals changing during cluster diffusion and to estimate their damaging effects on corresponding DNA molecules in given cells. The results demonstrating the influence of oxygen under different concentrations will be presented.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.
The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Barilla, J., Lokajíček, M., Pisaková, H. et al. Simulation of the influence of oxygen on the chemical stage of radiobiological mechanism using Petri nets. J Cheminform 6 (Suppl 1), P12 (2014). https://doi.org/10.1186/1758-2946-6-S1-P12
- Mathematical Model
- Energy Transfer
- Charged Particle
- Chemical Species