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Table 1 Mean Absolute Error (calculated by 10-fold cross-validation) in the prediction of log K t:p value by different decision tree-based regression methods, for each tissue, in K t:p -target dataset (with 110 compounds)

From: Predicting volume of distribution with decision tree-based regression methods using predicted tissue:plasma partition coefficients

Tissue M5P-4 M5P-6 M5P-8 M5P-10 M5P-RegTree REP-Tree M5-Rules Bagging (M5P)
muscle 0.3029 0.3040 0.3164 0.2950 0.3384 0.3857 0.3172 0.3228
brain 0.4695 0.4797 0.4869 0.4768 0.5387 0.5347 0.5170 0.4613
intestine 0.5939 0.4700 0.5337 0.5245 0.4523 0.4698 0.6060 0.5361
lung 0.4549 0.4812 0.4755 0.4776 0.5710 0.5522 0.5114 0.4822
spleen 0.9824 1.0069 1.0276 1.0206 0.8149 0.7997 0.8783 0.7857
heart 0.3391 0.3076 0.2991 0.3321 0.3562 0.4116 0.3723 0.3358
skin 0.2844 0.2752 0.2954 0.2666 0.3436 0.3433 0.2782 0.2961
bone 0.6210 0.7101 0.5893 0.5735 0.5109 0.5847 0.5724 0.4762
adipose 0.3581 0.4106 0.4186 0.4005 0.4557 0.5268 0.4031 0.3214
kidneys 0.2848 0.2706 0.2756 0.2736 0.3226 0.4035 0.2913 0.2281
liver 0.5495 0.5634 0.5036 0.5091 0.4925 0.5569 0.5879 0.4608
gut 0.6484 0.6134 0.6056 0.4905 0.4695 0.3912 0.4135 0.3169
thymus 0.3943 0.3599 0.3667 0.3601 0.2633 0.2176 0.3529 0.2623