Table 2 14 target proteins for molecular docking
From: Quantitative modeling of dose–response and drug combination based on pathway network
Target | Protein name | UniProt ID | PDB ID |
|---|---|---|---|
TLR4 | toll-like receptor 4 | O00206 | 4G8A |
PGES | Prostaglandin E synthase | O14684 | 3DWW |
TAK1 | MAP3K7 | O43318 | 2YIY |
AP-1 | Transcription factor AP-1 | P05412 | 1FOS |
NF-κB | Nuclear factor NF-kappa-B | P19838 | 3GUT |
ERK | ERK-1 | P27361 | 2ZOQ |
COX-2 | COX-2 | P35354 | 3LN1* |
JNK | c-Jun N-terminal kinase | P45983 | 3PZE |
MKK4/7 | mitogen-activated protein kinase kinase 4 | P45985 | 3ALN |
MKK3/6 | mitogen-activated protein kinase kinase 6 | P52564 | 3FME |
p38 | p38 MAP kinase | P53778 | 1CM8 |
MEK1/2 | mitogen-activated protein kinase kinase 1 | Q02750 | 3DY7 |
TRAF6:RIP1 | RIP1 | Q13546 | 4ITJ |
TRAF6 | TNF receptor-associated factor 6 | Q9Y4K3 | 1LB5 |