Table 3 Shows the types of data we used the drug target interaction having more than 1 and 2 drug interactions, area under the accumulated curve (AUAC), area under the ROC curve (AUC), bedroc and, enrichment factor (EF) and AUC Top 10%
From: Optimizing drug–target interaction prediction based on random walk on heterogeneous networks
Data types | Number of targets | AUAC (%) | AUC (%) | BEDROC | EF | AUC (Top 10%) |
|---|---|---|---|---|---|---|
ChEMBL 1 μM (RWR) | >0 | 0.709 | 0.995 | 0.433 | 5.058 | 0.455 |
ChEMBL 1 μM (Seq) | >0 | 0.670 | 0.670 | 0.396 | 4.48 | 0.414 |
ChEMBL 1 μM (random RWR) | >0 | 0.494 | 0.493 | 0.075 | 1.090 | 0.079 |
ChEMBL 10 μM (RWR) | >0 | 0.596 | 0.837 | 0.323 | 3.865 | 0.351 |
ChEMBL 10 μM (Seq) | >0 | 0.518 | 0.518 | 0.237 | 2.641 | 0.2555 |
ChEMBL 10 μM (random RWR) | >0 | 0.394 | 0.364 | 0.036 | 0.954 | 0.029 |
ChEMBL 1 μM (RWR) | >1 | 0.784 | 0.784 | 0.553 | 6.286 | 0.569 |
ChEMBL 1 μM (Seq) | >1 | 0.652 | 0.651 | 0.390 | 4.507 | 0.412 |
ChEMBL 1 μM (random RWR) | >1 | 0.483 | 0.483 | 0.081 | 1.290 | 0.083 |
ChEMBL 10 μM (RWR) | >1 | 0.613 | 0.61 | 0.353 | 4.091 | 0.378 |
ChEMBL 10 μM (Seq) | >1 | 0.551 | 0.552 | 0.279 | 3.084 | 0.300 |
ChEMBL 10 μM (random RWR) | >1 | 0.514 | 0.514 | 0.075 | 1.244 | 0.088 |
ChEMBL 1 μM (RWR) | >2 | 0.823 | 0.824 | 0.611 | 6.866 | 0.631 |
ChEMBL 1 μM (Seq) | >2 | 0.701 | 0.705 | 0.513 | 5.109 | 0.469 |
ChEMBL 1 μM | >2 | 0.533 | 0.533 | 0.0671 | 1.465 | 0.065 |
ChEMBL 10 μM (RWR) | >2 | 0.632 | 0.633 | 0.399 | 4.569 | 0.422 |
ChEMBL 10 μM (Seq) | >2 | 0.569 | 0.569 | 0.298 | 3.03 | 0.315 |
ChEMBL 10 μM (random RWR) | >2 | 0.521 | 0.521 | 0.262 | 1.95 | 0.125 |