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Table 9 Ranking based on ADME/T, promiscuous binders, diversity and similarity to Kalydeco

From: A reliable computational workflow for the selection of optimal screening libraries

Library ADME/T ranking Promiscuous binders Diversity ranking Similarity ranking Total ranka
Elite libraries 4 2 7 6 19 (5)
Platinum collection 6 1 8 2 17 (4)
DIVERSet™-CL 3 5 7 4 19 (5)
DIVERSet™-EXP 1 4 5 1 11 (1)
Drug-like set 3 6 3 3 15 (2)
Pharmacological diversity set 2 3 6 5 16 (3)
Maybridge screening collection 3 7 3 3 16 (3)
Prestwick Chemical Library® 7 9 1 7 24 (7)
MSII full library 5 8 2 6 21 (6)
  1. aThe “Total rank” column provides the sum of all rankings and in parenthesis, the final rank of each library