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# Table 2 Priors for implausible losses

Probability Loss type and molecular formulas
$$10^{-3}$$ Implausible losses: $$\hbox {C}_{2}\hbox {O}$$, $$\hbox {C}_{4}\hbox {O}$$, $$\hbox {C}_{3}\hbox {H}_{2}$$, $$\hbox {C}_{5}\hbox {H}_{2}$$, $$\hbox {C}_{7}\hbox {H}_{2}$$
$$\frac{1}{3^{ rdbe }}$$ Neutral losses with negative ring double bond equivalent RDBE
0.1 Nitrogen-only losses, carbon-only losses: for example, $$\hbox {N}_{5}$$ or $$\hbox {C}_{3}$$
1 All other neutral losses
0.9 Common radical losses: $$\hbox {H}^{\cdot }$$, $$\hbox {O}^{\cdot }$$, $${}^{\cdot }\hbox {OH}$$, $${}^{\cdot }\hbox {CH}_{3}$$, $$\hbox {CH}_{3}\hbox {O}^{\cdot }$$, $${}^{\cdot }\hbox {C}_{3}\hbox {H}_{7}$$, $${}^{\cdot }\hbox {C}_{4}\hbox {H}_{9}$$, $$\hbox {C}_{6}\hbox {H}_{5}\hbox {O}^{\cdot }$$
$$10^{-3}$$ All other radical losses
1. For an edge (uv) with loss $$u-v$$ let $$P_{\text{loss-impl}}(u,v)$$ be the prior for $$u-v$$ chosen according to this table. Expert knowledge and evaluation of FTs from SIRIUS2 resulted in the implausible losses listed here [41]. These losses should only very rarely (if ever) occur in a FT, so we manually select reduced priors