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Fig. 2 | Journal of Cheminformatics

Fig. 2

From: Comparative analysis of chemical similarity methods for modular natural products with a hypothetical structure enumeration algorithm

Fig. 2

Examples of original and modified structures generated by LEMONS. a A linear hybrid nonribosomal peptide/polyketide natural product containing an alicyclic starter unit is derivatized by substitution of an amino acid, the starter unit, and a polyketide monomer, in addition to chlorination and heterocyclization/oxidation to form a thiazole. b A macrocyclic polyketide is derivatized by substitution of two polyketide monomers and glycosylation by the deoxysugar actinosamine

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