Fig. 2From: Comparative analysis of chemical similarity methods for modular natural products with a hypothetical structure enumeration algorithmExamples of original and modified structures generated by LEMONS. a A linear hybrid nonribosomal peptide/polyketide natural product containing an alicyclic starter unit is derivatized by substitution of an amino acid, the starter unit, and a polyketide monomer, in addition to chlorination and heterocyclization/oxidation to form a thiazole. b A macrocyclic polyketide is derivatized by substitution of two polyketide monomers and glycosylation by the deoxysugar actinosamineBack to article page