Fig. 4
Wrapping tyrosine-protein kinase Src target into a mono-layer of ligand copies (System 5). a Unbound (ligand free) accessible surface area (ASA) of the target and the lowest Einter of the cluster representatives in consecutive wrapping cycles. Target-ligand interaction energy (Einter) increases with increasing number of cycles finding strong binding sites in the first few cycles, before the final, saturation region. ASA finally decreases below 1%. Structural images show the wrapping of the target (grey surface) with ligands (red). b The monolayer arrangement of the ligands (red sticks) wrapping the entire target surface (grey) after the final cycles. c A close-up of a section of the monolayer showing that the ligand copies are evenly arranged without overlap