Table 9 Chemical structures, Enamine codes, and inhibition percentages at given concentrations of the 30 compounds tested against both the acetylcholinesterase and thrombin assays
Enamine code and structure | Predicted targeta | Acetylcholinesterase assay/compound concentration (μM) | Thrombin assay/compound concentration (μM) | ||||||
|---|---|---|---|---|---|---|---|---|---|
25 | 10 | 2.5 | 1 | 100 | 50 | 25 | 10 | ||
| A | 48% | – | 3% | – | 0% | – | – | 0% |
| A | 31% | – | 0% | – | – | 4% | – | 0% |
| A | – | – | 0%b | – | – | – | 0% | 0% |
| A | – | 21% | 0% | – | – | – | 0% | 0% |
| A | – | 27% | 0% | – | – | – | 6% | 5% |
| A | – | – | 1%b | – | – | – | 0% | 0% |
| A | – | 18% | 0% | – | – | – | 0% | 0% |
| A | – | 0% | 0% | – | 0% | – | – | 0% |
| A | – | 25% (5 μM) | 8% | – | – | – | – | 0% |
| A | – | 0% | 0% | – | – | 0% | – | 0% |
| A | – | – | 75% | 60% | – | – | 0% | 0% |
| A | – | 22% | 7% | – | 0% | – | – | 0% |
| A | – | 4% | 1% | – | – | 0% | – | 0% |
| A | – | 41% | – | 14% | – | – | 0% | 0% |
| A | – | 44% | – | 14% | 9% | 2% | – | 0% |
| A | – | 1% | 2% | – | – | 0% | – | 0% |
| A | – | 8% (5 μM) | 0% | – | – | 0% | – | 0% |
| A | – | 0% | 0% | – | 4% | – | – | 0% |
| A | – | 0% | 0% | – | 0% | 0% | – | 0% |
| A | – | 11% | – | – | – | – | 0% | 0% |
| A | – | – | 82% | 51% (0.25 μM) | – | – | 0% | 0% |
| A | – | 31% | 16% | – | 0% | 0% | – | 0 |
| A | – | 32% | 11% | – | 0% | 0% | – | 0% |
| A | – | 10% | – | – | – | – | – | 0% |
| A | – | 35% | 7% | – | – | 6% | – | 0% |
| T | – | 48% | 19% | – | – | 7% | – | 0% |
| T | – | 31% | 8% | – | 0% | – | – | 0% |
| T | – | 23% | 0% | – | – | 0% | – | 0% |
| T | – | 0% | – | – | – | 4% | – | 0% |
| T | – | 0% | – | – | 0% | 0% | – | 0% |
