Table 1 The table shows the predicted drugs and their indications for the top 10 prioritized targets
From: RepTB: a gene ontology based drug repurposing approach for tuberculosis
Target/GeneID | Pathway | Known drug | Predicted drug | Predicted drug indication |
|---|---|---|---|---|
folP1/Rv3608c | Tetrahydrofolate biosynthesis | DB03592 | DB03705;DB04047;DB04196 | Antibacterial; antibacterial.; antibacterial |
panC/Rv3602c | (R)-pantothenate biosynthesis | DB01930; DB02596;DB02694;DB03107 | DB02355;DB03215;DB07706 | Antibacterial; antibacterial; antibacterial |
Tmk/Rv3247c | dTTP biosynthesis | DB01643;DB02452;DB03280;DB03666;DB03846;DB04160;DB04485 | DB01799;DB02480;DB02594;DB02745;DB03150*;DB03165;DB03195*;DB03233*;DB03723;DB03845*;DB04170 | Antibacterial; antibacterial; antibacterial; bipolar disorder; antiviral; antibacterial; anti-cancer; antibacterial; antibacterial; anti-cancer; antibacterial |
dapB/Rv2773c | Lysine biosynthesis | DB04267 | DB03969 | Antibacterial |
Dut/Rv2697c | dUMP biosynthesis | DB01965;DB02333;DB03413;DB03800 | DB04685* | Antifungal |
ftsZ/Rv2150c | Cell division | DB01864;DB04272;DB04315 | DB00150;DB02082*;DB02547;DB02623*;DB02703;DB02975;DB03171;DB04124;DB04261;DB04723;DB06835;DB06921;DB07136;DB07157;DB07182;DB07269;DB08185 | Nutraceutical; membrane transport inhibition; antibacterial; unknown; antibacterial; antibacterial; antibacterial; antibacterial; antibacterial; unknown; unknown; unknown; unknown; unknown; unknown; unknown; antibacterial |
inhA/Rv1484 | Mycolic acid biosynthesis | DB00609;DB00951;DB02990;DB04289;DB07090;DB07123;DB07155;DB07178;DB07188;DB07192;DB07222;DB07287;DB08604 | DB04007;DB04393*;DB05291;DB07453;DB08605*;DB08607 | Antibacterial; antibacterial; anesthetic; unknown; antibacterial; unknown |
ribH/Rv1416 | Riboflavin biosynthesis | DB01692;DB02135;DB02184;DB02290;DB02693;DB02711;DB03022;DB03812;DB03973;DB08016 | DB02452 | Antibacterial |
mshD/Rv0819 | Mycothiol biosynthesis | DB01992 | DB01669;DB01764;DB01783;DB01846;DB01856;DB02516;DB03134;DB03230;DB03699;DB03905;DB03912 | Antibacterial; antibacterial; obesity; antibacterial; unknown; antibacterial; unknown; antibacterial; unknown; unknown; antibacterial |
menB/Rv0548c | Menaquinone biosynthesis | DB01992;DB03059 | DB01669;DB01764;DB01783;DB01846;DB01856;DB02039;DB02516;DB03134;DB03230;DB03612;DB03699;DB03905;DB03912 | Antibacterial; antibacterial; obesity; antibacterial; Unknown; antibacterial; antibacterial; unknown; antibacterial; mitochondrial beta oxidation; unknown; unknown; antibacterial |