Skip to main content

Table 1 The table shows the predicted drugs and their indications for the top 10 prioritized targets

From: RepTB: a gene ontology based drug repurposing approach for tuberculosis

Target/GeneID Pathway Known drug Predicted drug Predicted drug indication
folP1/Rv3608c Tetrahydrofolate biosynthesis DB03592 DB03705;DB04047;DB04196 Antibacterial; antibacterial.; antibacterial
panC/Rv3602c (R)-pantothenate biosynthesis DB01930; DB02596;DB02694;DB03107 DB02355;DB03215;DB07706 Antibacterial; antibacterial; antibacterial
Tmk/Rv3247c dTTP biosynthesis DB01643;DB02452;DB03280;DB03666;DB03846;DB04160;DB04485 DB01799;DB02480;DB02594;DB02745;DB03150*;DB03165;DB03195*;DB03233*;DB03723;DB03845*;DB04170 Antibacterial; antibacterial; antibacterial; bipolar disorder; antiviral; antibacterial; anti-cancer; antibacterial; antibacterial; anti-cancer; antibacterial
dapB/Rv2773c Lysine biosynthesis DB04267 DB03969 Antibacterial
Dut/Rv2697c dUMP biosynthesis DB01965;DB02333;DB03413;DB03800 DB04685* Antifungal
ftsZ/Rv2150c Cell division DB01864;DB04272;DB04315 DB00150;DB02082*;DB02547;DB02623*;DB02703;DB02975;DB03171;DB04124;DB04261;DB04723;DB06835;DB06921;DB07136;DB07157;DB07182;DB07269;DB08185 Nutraceutical; membrane transport inhibition; antibacterial; unknown; antibacterial; antibacterial; antibacterial; antibacterial; antibacterial; unknown; unknown; unknown; unknown; unknown; unknown; unknown; antibacterial
inhA/Rv1484 Mycolic acid biosynthesis DB00609;DB00951;DB02990;DB04289;DB07090;DB07123;DB07155;DB07178;DB07188;DB07192;DB07222;DB07287;DB08604 DB04007;DB04393*;DB05291;DB07453;DB08605*;DB08607 Antibacterial; antibacterial; anesthetic; unknown; antibacterial; unknown
ribH/Rv1416 Riboflavin biosynthesis DB01692;DB02135;DB02184;DB02290;DB02693;DB02711;DB03022;DB03812;DB03973;DB08016 DB02452 Antibacterial
mshD/Rv0819 Mycothiol biosynthesis DB01992 DB01669;DB01764;DB01783;DB01846;DB01856;DB02516;DB03134;DB03230;DB03699;DB03905;DB03912 Antibacterial; antibacterial; obesity; antibacterial; unknown; antibacterial; unknown; antibacterial; unknown; unknown; antibacterial
menB/Rv0548c Menaquinone biosynthesis DB01992;DB03059 DB01669;DB01764;DB01783;DB01846;DB01856;DB02039;DB02516;DB03134;DB03230;DB03612;DB03699;DB03905;DB03912 Antibacterial; antibacterial; obesity; antibacterial; Unknown; antibacterial; antibacterial; unknown; antibacterial; mitochondrial beta oxidation; unknown; unknown; antibacterial