Dataset
|
Number of compounds
|
Intra-set similarity median (Tc)
|
Average “1” bits
|
Number of “1” bits in DFP
|
Number of “1” bits in SB-DFP
|
---|
MACCSa
|
ECFP4b
|
MACCSa
|
ECFP4b
|
MACCSa
|
ECFP4b
|
MACCSa
|
ECFP4b
|
---|
BRD2
|
234
|
0.569
|
0.152
|
56.0
|
54.3
|
53
|
27
|
67
|
229
|
BRD3
|
246
|
0.573
|
0.153
|
56.6
|
54.6
|
53
|
26
|
73
|
231
|
BRD4
|
477
|
0.486
|
0.133
|
55.9
|
52.8
|
47
|
14
|
71
|
333
|
CREBBP
|
105
|
0.694
|
0.276
|
56.1
|
53.9
|
52
|
36
|
50
|
185
|
DNMT1
|
127
|
0.403
|
0.115
|
55.4
|
51.7
|
50
|
13
|
62
|
281
|
EHMT2
|
61
|
0.636
|
0.228
|
62.4
|
55.7
|
62
|
41
|
56
|
167
|
EP300
|
57
|
0.425
|
0.106
|
58.2
|
55.7
|
53
|
11
|
56
|
285
|
HDAC10
|
190
|
0.514
|
0.165
|
53.2
|
50.6
|
50
|
17
|
46
|
272
|
HDAC11
|
137
|
0.494
|
0.156
|
51.2
|
50.8
|
48
|
16
|
42
|
229
|
HDAC1
|
2740
|
0.453
|
0.149
|
53.2
|
51.4
|
51
|
15
|
63
|
499
|
HDAC2
|
767
|
0.447
|
0.149
|
50.3
|
48.4
|
46
|
13
|
53
|
336
|
HDAC3
|
669
|
0.474
|
0.147
|
52.6
|
50.3
|
49
|
13
|
54
|
356
|
HDAC4
|
452
|
0.427
|
0.135
|
50.4
|
46.4
|
42
|
10
|
49
|
248
|
HDAC5
|
112
|
0.455
|
0.153
|
47.3
|
44.1
|
39
|
13
|
26
|
176
|
HDAC6
|
1374
|
0.474
|
0.149
|
54.3
|
49.8
|
48
|
13
|
62
|
415
|
HDAC7
|
112
|
0.489
|
0.165
|
50.4
|
45.8
|
43
|
12
|
28
|
197
|
HDAC8
|
864
|
0.500
|
0.153
|
54.9
|
51.2
|
50
|
12
|
52
|
398
|
HDAC9
|
102
|
0.494
|
0.169
|
52.6
|
47.4
|
46
|
13
|
29
|
190
|
KAT2B
|
55
|
0.583
|
0.179
|
50.8
|
37.3
|
46
|
13
|
44
|
99
|
KDM1A
|
241
|
0.380
|
0.143
|
44.8
|
46.2
|
31
|
21
|
31
|
216
|
KDM4C
|
88
|
0.359
|
0.101
|
48.8
|
40.3
|
41
|
10
|
38
|
158
|
L3MBTL1
|
50
|
0.804
|
0.551
|
42.2
|
36.8
|
37
|
27
|
37
|
56
|
L3MBTL3
|
89
|
0.731
|
0.404
|
40.4
|
36.6
|
37
|
26
|
35
|
83
|
MAP3K7
|
96
|
0.539
|
0.137
|
57.1
|
60.5
|
59
|
35
|
45
|
190
|
MGEA5
|
67
|
0.683
|
0.316
|
54.2
|
39.6
|
48
|
19
|
42
|
126
|
NCOA1
|
51
|
0.350
|
0.105
|
45.5
|
43.3
|
34
|
11
|
18
|
132
|
NCOA3
|
157
|
0.368
|
0.109
|
47.7
|
44.6
|
39
|
10
|
26
|
166
|
PRMT1
|
61
|
0.395
|
0.076
|
53.0
|
53.5
|
41
|
9
|
40
|
239
|
Average
|
350
|
0.507
|
0.178
|
52
|
48
|
46
|
18
|
46
|
232
|
- aMACCS keys 166-bit
- bECFP4 2048-bit