Fig. 5

An illustration of the crystallographic and docked poses of folic acid bound to the human folate receptor beta. The carbon atoms of the protein, the crystallographic ligand, the docked Gypsum-DL compound, and the docked Open-Babel compound are shown in green, yellow, gray, and pink, respectively. a The region of the pocket near R152. b The Gypsum-DL-prepared compound forms additional interactions with other protein residues (in green). Possible hydrogen bonds are shown as dotted lines. c The crystallographic pose, shown for reference. Image generated using BlendMol [33]