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Table 1 Comparison of the Bemis–Murcko scaffold and the core framework proposed in this work

From: A general approach for retrosynthetic molecular core analysis

Feature Bemis–Murcko scaffold Core framework
Number of cores per molecule 0 or 1 1 or more
Rings can be substituents No Yes
Considers retrosynthesis rules No Yes
The core is a major component of the molecule Yes/no Yes