Table 1 Comparison of the Bemis–Murcko scaffold and the core framework proposed in this work
From: A general approach for retrosynthetic molecular core analysis
Feature | Bemis–Murcko scaffold | Core framework |
|---|---|---|
Number of cores per molecule | 0 or 1 | 1 or more |
Rings can be substituents | No | Yes |
Considers retrosynthesis rules | No | Yes |
The core is a major component of the molecule | Yes/no | Yes |