Fig. 11
From: “Molecular Anatomy”: a new multi-dimensional hierarchical scaffold analysis tool
a Network corresponding to the cluster of molecules having the same basic wireframe shown in panel (c). b The same network is simplified by removing nodes with EF values equal to 0, that is molecules and scaffolds not relevant in terms of SAR information. Nodes correspond to the molecules, on the top of the hierarchical visualization colored in purple with a border width depending on the activity class, and to the relative molecular frameworks, colored according to the EF value reported as label of the node (from orange to green in the direction of ascending values) and sized according to the number of actives