Table 4 BR prediction performance on HOLO4K test dataset
From: Sequence-based prediction of protein binding regions and drug–target interactions
Name | HOLO4K unseen protein–ligand complexes) | HOLO4K (unseen proteins) | ||
|---|---|---|---|---|
Top-n success rate (%) | Top-(n + 2) success rate (%) | Top-n success rate (%) | Top-(n + 2) success rate (%) | |
Fpocket | 61.1 | 67.2 | 58.4 | 62.6 |
SiteHound | 64.9 | 78.2 | 57.9 | 70.3 |
MetaPocket 2.0 | 70.9 | 82.2 | 65.4 | 75.8 |
DeepSite | 60.6 | 65.7 | 64.3 | 70.5 |
P2Rank | 78.1 | 89.3 | 74.4 | 86.5 |
HoTS (proposed) | 61.4 ± 0.7 | 79.1 ± 0.4 | 53.2 ± 0.6 | 71.7 ± 0.6 |