Table 1 Changes of the plasma concentration when two drugs are combined
From: Machine learning to predict metabolic drug interactions related to cytochrome P450 isozymes
Drug 1/2 | Inhibitor | Substrate | Both |
|---|---|---|---|
Inhibitor | Affect other drugs metabolized by the isozyme | Cp of Drug 1 will increase | Cp of Drug 1 will increase |
Substrate | Cp of Drug 2 will increase | If bind the same active site, Cp of Drug 1, 2 will increase | Cp of Drug 1, 2 will increase |
Both | Cp of Drug 2 will increase | Cp of Drug 1, 2 will increase | Cp of Drug 1, 2 will increase |