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Table 1 Changes of the plasma concentration when two drugs are combined

From: Machine learning to predict metabolic drug interactions related to cytochrome P450 isozymes

Drug 1/2 Inhibitor Substrate Both
Inhibitor Affect other drugs metabolized by the isozyme Cp of Drug 1 will increase Cp of Drug 1 will increase
Substrate Cp of Drug 2 will increase If bind the same active site, Cp of Drug 1, 2 will increase Cp of Drug 1, 2 will increase
Both Cp of Drug 2 will increase Cp of Drug 1, 2 will increase Cp of Drug 1, 2 will increase
  1. Cp: the drug concentration in plasma