Table 1 Target-liability reference
From: ProfhEX: AI-based platform for small molecules liability profiling
Liability | Targets |
|---|---|
CV (25) | ACHE, ADORA2A, ADRA1A, ADRA2A, ADRB2, AVPR1A, CHRM1, DRD1, DRD2, HRH1, HRH2, HTR1B, HTR2A, HTR2B, KCNH2, MAOA, OPRD1, OPRK1, OPRM1, PDE3A, PTGS2, SCN5A, SLC6A2, SLC6A4 |
CNS (19) | ADORA2A, ADRA1A, ADRA2A, CHRM1, CNR1, DRD1, DRD2, EDNRA, HTR1A, HTR1B, HTR2A, MAOA, OPRD1, OPRK1, OPRM1, PDE4D, SLC6A2, SLC6A3, SLC6A4 |
GI (13) | ACHE, ADRA1A, ADRB1, CCKAR, CHRM1, CHRM3, HRH2, HTR3A, OPRK1, OPRM1, PPARA, PPARD, PTGS1 |
ED (7) | AR, DRD2, EDNRA, ESR1, HTR1A, HTR3A, NR3C1 |
PU (5) | ACHE, ADRB2, CHRM3, HTR2B, PTGS1 |
RE (2) | AVPR1A, PTGS1 |
IM (6) | CNR2, HRH1, LCK, NR3C1, PDE4D, PTGS2 |