Fig. 3
From: Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors
Results of cell viability assay with A A549 and B HT29 cell lines. To evaluate the cellular efficacy of the compounds against cancer cells, A549 lung cancer and HT29 colon cancer cells were selected to observe the relation between the cancer cell growth inhibition and MEK inhibition. PD98059 is a known selective cell permeable inhibitor for MEK1 (IC50 = 2 ~ 7 µM) and MEK2 (IC50 = 50 µM) and was used as a positive control in the present study. The two MEK inhibitors (ZINC5814210 and ZINC32911363) showed activity against A549 and HT29 cancer cells, especially at higher concentrations