Table 3 Cross inhibitory activity (Kd, nM) of the three MEK1 inhibitors to the MEK isoforms
From: Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors
Compound Name | MEK1 | MEK2 | MEK5 |
|---|---|---|---|
ZINC5814210 | 1000 | 1750 | 120 |
ZINC5479148 | 2400 | 5350a | 235 |
ZINC32911363 | 3850a | > 10,000a | 3950a |