Fig. 11
From: Analysis of metabolites in human gut: illuminating the design of gut-targeted drugs
Statistical analysis for the association between different physicochemical properties with gut permeation at the different chemical classes. For all the physicochemical property vs chemical class combination, a non-parametric Mann–Whitney test comparing the distributions in the “Gut Ligerer noFL” set vs the “Gut Traverser” set was performed. Red cells correspond to significant (p-value < 0.05 after Benjamini–Hochberg false discovery rate correction) with a CLES < 0.5, while blue cells correspond to significant test with CLES > 0.5. White cells correspond to non-significance. By reversing the colors we would obtain the significantly higher and lower combinations in “Gut Traversers”. Only shown chemical classes present in both gut permeation sets