Fig. 4

The binding site-prediction accuracy of CoBDock compared with state-of-art methods. The binding site-prediction accuracy of CoBDock was compared with four representative pocket identification algorithms (Fpocket, P2Rank, CB-Dock and CB-Dock1). The mean distance is the mean distance between the centroid of the ground true binding site and the centroid of the predicted binding site. Likewise, median distance is the median distance between true and predicted pocket centroids, better accounting for outliers. Accuracy (within 8 Å) is the proportion of predicted binding sites whose centroid was within a threshold of 8 Å of the centroid of the true binding site