Table 3 Summary of the reasons for rejecting entries obtained through data curation using the original articles
From: A new workflow for the effective curation of membrane permeability data from open ADME information
Rejection reason | Number of unique entries | Number of unique chembl_id values | Number of unique doc_id values | Number of unique assay_id values | Number of entries of autocuration in curated_by columns in the assay table |
|---|---|---|---|---|---|
Ambiguous cell lines from the original article | 350 | 323 | 86 | 97 | 343 |
Average of apical to basolateral and basolateral to apical velocities | 91 | 91 | 8 | 8 | 91 |
Different cell lines (such as Caco-2, 2/4/A1, PAMPA, and Lucifer Yellow Permeability) | 152 | 108 | 24 | 36 | 129 |
From basolateral to apical (in description) | 372 | 310 | 67 | 88 | 317 |
Expressing MDR1 (p-glycoprotein) and BCRP | 731 | 667 | 119 | 133 | 596 |
Different pH (pH 5.5 or 6.5) | 4 | 2 | 1 | 2 | 4 |
Measurements of efflux ratio | 3 | 3 | 1 | 1 | 0 |