- Poster presentation
- Open Access
Free-Wilson in the 21st Century – evolution of a versatile toolkit for SAR analysis
© Sherborne; licensee BioMed Central Ltd. 2011
- Published: 19 April 2011
- 21st Century
- Drug Discovery
- Chemistry Input
- Discovery Project
- Numerical Detail
In this talk it is shown how a carefully crafted PDF report can be combined with “on the fly” Matched Molecular Pair  and other drill downs to provide a versatile platform for SAR exploration and presentation that is appealing and to medicinal chemists.
- Free SM, Wilson JW: A Mathematical Contribution to Structure-Activity Studies. J Med Chem. 1964, 7: 395-399. 10.1021/jm00334a001.View ArticleGoogle Scholar
- Leach AG, Jones HD, Cosgrove DA, Kenny PW, Ruston L, MacFaul P, Wood JM, Colclough N, Law B: Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure. J Med Chem. 2006, 49: 6672-6682. 10.1021/jm0605233.View ArticleGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.