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Table 1 Dependence of ligand efficiency on C°

From: The nature of ligand efficiency

N nH b KD/Mc ηbind (C°)a
C° = 0.1 M C° = 1 M C° = 10 M
10 10−3 0.20 0.30 0.40
20 10−6 0.25 0.30 0.35
30 10−9 0.27 0.30 0.33
  1. aLigand efficiency defined in (11)
  2. bNumber of non-hydrogen atoms in molecular structure
  3. cDissociation constant for protein–ligand complex
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